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These model systems provided direct support for the "protein-only" hypothesis and indicated that fungal prions correspond to self-propagating amyloid or amyloid-like assemblies [9] [13].
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We show here that MD simulations of model systems provide a molecular-level rationale for this observation.
Fluorescence microscopy studies using giant unilamellar vesicles (GUVs) as membrane model systems provide a unique methodology to quantify protein binding, interaction, and lipid solubilization in artificial bilayers.
Model systems provide more favorable conditions for observing phenomena and testing hypotheses than other systems afford.
Model systems provide useful tools to assess the effects of established compounds in different clinical situations.
It necessitates the development of new model systems providing parameters predictive for NM action in various disorders and pathophysiological conditions.
Hence, prediction of lncRNAs' functions with multiple model systems provides guideline for further experimental investigations [ 7, 8].
Although assays based on cell lines are useful, whole animal model systems provide much more relevant information on the activity and possible side effects of novel compounds.
Moreover, studies in other model systems provide direct evidence that the TGF-β pathway can suppress the Wnt/β-catenin pathway [ 35- 37].
Insect model systems provide powerful tools for probing virus-host interactions but have primarily focused on Dipteran hosts (Kingsolver et al., 2013).
The data generated from these model systems provide important information that could promote the understanding of starch metabolism and carotenoid accumulation during the ripening process in other plant systems.
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