Sentence examples for model systems often from inspiring English sources
These 3D model systems often are able to mimic human physiology more accurately than traditional 2D cultures and animal models.
Current 2-dimensional hepatic model systems often fail to predict chemically induced hepatotoxicity due to the loss of a hepatocyte-specific phenotype in culture.
Although general toxic or positive therapeutic effects can be investigated in vivo using suitable animal models, these model systems often do not allow to distinguish between direct effects, or indirect and bystander effects on target tissues.
Due to their simplicity, these static, monoculture model systems often represent suboptimal models for drug and chemical safety testing that are not able to mimic or predict more complex MOA.
There are increasing efforts to bring high-throughput systems biology techniques to bear on complex animal model systems, often with a goal of learning about underlying regulatory network structures (e.g., gene regulatory networks).
In most studies, only one pollinator species was investigated at a time, frequently in very specialized model systems, often the sexually deceptive pollination systems of orchids (Schiestl, 2005; Schiestl and Schlüter, 2009).
The experimental methods that work in one model system often require tweaking or complete rethinking to be used in a different organism.
Krasnow said he turned to lemurs out of frustration with studies in mice, which make up the vast majority of animal model systems but often don't mimic human biology and behavior.
Much of our knowledge on the functions of genes, both in health and disease, is derived from molecular biological experiments with specific model systems, which often provide a biased and context-specific view of gene functions.
Structural features of these reactions are identified by ESR spectroscopy in model systems and often in cells.
Experimental protocols developed in the model systems are often readily portable to less well-studied sister species, allowing us to choose species well-placed to identify and study functional divergence.
