Sentence examples for model systems found from inspiring English sources

Primary studies within different model systems found that at least one ALS mutation (p.A315T) in TARDBP, or a disruption of the nuclear localization signal (NLS) enhanced cytoplasmic mislocalization increasing toxicity in the absence of TDP-43 aggregates (72, 105– 105).

Likewise, not all studies on presenilin-null model systems find evidence for slowed turnover of autophagic substrates or changes in lysosomal acidification/function [ 36].

Also studies in Drosophila melanogaster, employing huntingtin and ataxin as model systems find genes in signal transduction and cellular proteostasis [ 50].

To address this question, Larsson and Hougaard (1994) have immobilized oligonucleotides on glass slides and with this "ideal" model system found a nearly logarithmic relationship between probe optical density and target oligonucleotide concentration over two to three orders of magnitude [43].

For addition details, the data files, and the R-code used to find model systems, see the Open Lab Notebook page [11].

Using in vitro model systems, we found that EEF1A2 is involved in regulating cell cycle progression and survival of PCT.

We used E. coli grown on limiting concentrations of ammonia or glucose as model systems and found that when the bacteria run out of substrate, growth stops abruptly.

Mutations in these model systems are found in the C-terminal region, suggesting that it is this region of the protein that is required for vision.

Taken together, data from multiple investigators using different model systems have found that SIN3 is necessary for regulation of key metabolic processes.

Consistent with data obtained in higher model systems, we found that a small portion of α-synuclein localized to purified mitochondria of yeast cells heterologously expressing human α-synuclein.

Amazingly, Americans, a people stereotypically allergic to abstract systems, found this model of the mind irresistible.