Sentence examples for model systems evidence from inspiring English sources
Indeed, even though RBM47 loss was associated with metastatic cancer clones in our model systems, evidence for selection against RBM47 was detected already in primary breast cancers.
Likewise, not all studies on presenilin-null model systems find evidence for slowed turnover of autophagic substrates or changes in lysosomal acidification/function [ 36].
Moreover, studies in other model systems provide direct evidence that the TGF-β pathway can suppress the Wnt/β-catenin pathway [ 35- 37].
Liver specific knock-out [ 42] or overexpression [ 43, 44] of gk in mammalian model systems provide unequivocal evidence that hepatic GK regulates blood glucose homeostasis by limiting hepatic glucose utilization for glycogen synthesis and the de novo lipogenic pathway.
Using the Asp-family and AAA metabolic networks of amino acid metabolism as model systems, we also provide evidence indicating that HCGs are central regulatory genes within specific biological networks, as evident from their tight negatively or positively coordinated expression with other genome-wide genes under different biological perturbations.
Interesting, from other model systems there is some evidence that blockade of cell division in the mediobasal hypothalamus using anti-mitotic compounds or irradiation ameliorated leptin- (Kokoeva et al., 2005) and high fat diet- (Lee et al., 2012) induced changes in metabolism, suggesting a causal role for cell division in hypothalamic function.
These two fields of study used different standards of evidence and model systems and looked at different sets of problems (Atkinson 1992; Burian 2000; Love 2009).
From the foregoing, there is evidence from model systems that COX-2 induction involves NF- κB.
There is now strong evidence from model systems to suggest that MMPs are involved in both tumour initiation and progression.
The transforming potential of the IRS proteins has been demonstrated in several different model systems, with most of the evidence coming from studies on IRS-1.
Using these model systems, we provide strong experimental evidence that genetic deletion of Nr2f6 is both necessary and sufficient to induce host-protective immune rejection of cancer.
