Such model systems do typically arise in geobiochemical modelling where the reproduction of these properties is vital.
Comparison of tight junctions (TJ) in untreated versus LT-treated 3D model systems did not reveal clear differences in ZO1 distribution between two adjacent cells (Figure 1C).
However, these traditional model systems do not allow direct studies of the interaction between infectious fungal spores and innate immune cells.
This common design principle is significant for two reasons: first, many human kidney pathologies involve filtrate flow (see below); and second, the excretory systems of existing invertebrate model systems do not recapitulate this critical aspect.
The P.chabaudi model system does however give us a wealth of experimental data which may help us develop hypotheses for the regulation of potentially more complex human malaria infections.
Because this model system does not accurately reflect the metastatic process, does this work reflect human breast cancer metastasis, or even tissue-specific metastasis?
It was previously established that the neurological symptoms in CSB-deficient mice are not as severe as in humans and that CSB mouse model system does not recapitulate the human CSB phenotype.
While there is no basis for believing that the mechanism that prevents involucrin induction in SCC4 cells is exactly the same as that which prevents involucrin expression in the hypoxic regions of poorly differentiated squamous cell carcinomas, the model system does show that dedifferentiation can suppress involucrin induction by hypoxia.
In fact, Gelsemium s. 2c at the lowest dilution (highest dose) tested in this model system did not cause cell toxicity or viability impairment.
Both modeling systems did not capture most of the variability of the high-frequency, intra-day component for all variables for which hourly measurements were available.
