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These 3D tissue-like model systems can reduce the uncertainty involved in extrapolating risk between in vitro cellular and in vivo models.
Moreover, regression of liver fibrosis in these model systems can be stimulated with drugs that target the activities of fibrogenic hepatic stellate cells.
For example, the calibration of new, emerging model systems, can benefit from data fusion from diverse sources, as each measurement may be more suitable to the calibration of some subset of parameters.
Structural and functional characterization of integrative cartilage repair in controlled model systems can play a key role in the development of innovative strategies to improve the long-term outcome of many cartilage repair procedures.
The common characteristics of amyloid and amyloid-like fibrils from disease- and non-disease-associated proteins offer the prospect that well-defined model systems can be used to systematically dissect the driving forces of amyloid formation.
Using water as a source of electrons and sunlight as a source of energy, both engineered natural systems and biomimetic (bio-inspired) model systems can be designed as first steps towards water-splitting-based hydrogen production (biophotolytic hydrogen production).
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The model system can be relevant to regulation of lateral organization of ion channels and other components in natural membrane systems.
In many cases it has been proved that the introduction of stochastic perturbations into an ode epidemic model system can possibly render an unstable disease-free equilibrium of the ode system to become stable in the stochastic differential equation system.
The diameter of the wires was set to 80 nm, with a lattice parameter of 180 nm and a height of 15 μm (a schematic view of the model system can be seen on top of Figure 1a).
In addition, we suggest that this planktonic biofilm model system can provide the basis for a detailed analysis of the synchronized biofilm life cycle of P. aeruginosa.
Thus, this model system can serve as an early provider of potential biomarkers.
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