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If I continue in academia, I am interested in continuing to expand the repertoire of model systems available to molecular biologists through embryology, CRISPR genome editing, and genomics.
In this perspective, we discuss the unique features of metastatic disease and review the model systems available for drug profiling.
Despite the range of model systems available, similar studies into disease processes underlying reactivated TB in HIV-infected humans with latent TB have yet to be done.
Preclinical testing of immune-based therapies is often hindered by the model systems available.
In vitro growing cell lines are the closest model systems available today for studying the biological features of body cavity lymphomas.
The zebrafish mutants described here will be a useful addition to the model systems available to study vestibular disorders associated with otoconial abnormality.
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Accurate prediction of essential genes is important for identification of drug targets to combat the emergence of pathogens and antibiotic-resistant bacteria20, especially for serious infectious agents for which there is no research model system available.
However, it does recapitulate many of the important immune aspects of cerebral malaria and is the best model system available to study the early steps in cerebral malaria pathogenesis [2], [53].
In this review, we explore the deleterious effects of toxic RNA expression and discuss the various model systems currently available for studying RNA gain-of-function in neurologic diseases.
Toxicity of these proteins has been previously identified only in mammals, and no simple model systems are available.
Thirdly, different AML mouse model systems are available, which rely on transduction of distinct oncogenes with varying latency periods, and hence provide a suitable platform to identify shared pathways of general relevance for leukaemogenesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com