The use of different animal prion disease isolates (and possibly differing species and strains of CWD) might explain this discrepancy; however, a more fundamental difference might be that the in vivo and in vitro model systems assess different aspects of the agent and its replication.
Here we review fundamental, genetic, and clinical arguments on which the therapeutic strategies for design of secretase agonists and antagonists are based, with special attention to physiological model systems to assess the potential of current efforts.
Gene knockout and transgenic technology has facilitated the development of mouse strains that can be used as model systems to assess tumor development and treatment.
Thus, the merovingian mutant and zebrafish lateral line might be useful model systems to assess the role of pH regulation in hair cell function.
Clearly, there is a need to develop more physiologically-relevant, long-term culture model systems for assessing toxicity, conducting in vitro-in vivo extrapolation (IVIVE) and supporting development of physiologically-based pharmacokinetic (PBPK) models of chemical disposition and toxicity.
The prostate cancer xenograft model PC295 was used as a model system to assess the value of DCE-MRI-derived parameters in studying the heterogeneous uptake of radiolabeled peptide 111In(DOTA- βAla 2-JMV594 in DOTA- βAla 2-JMV594 in DOTA- βAla 2-JMV594 in
Using the Greek Island of Lesvos as a model system, we assess the biodiversity value of six common habitats and measure ecosystemic 'health' using pollen grain deposition in three core flowering plants as a measure of pollination services.
In summary, we have described the use of the aquatic plant duckweed as a model system for assessing the virulence of human pathogenic bacteria as well as assessing the therapeutic potential of anti-bacterial compounds.
In order to evaluate an in vivo model system for assessing the effect of therapeutic and residue levels of tetracycline on human intestinal microflora, tetracycline was administered via drinking water (1, 10, and 100 mg/liter) to human-flora-associated (HFA) male and female mice.
Here, we used a within-genus model system to assess the extent of LTR substitution rates by scanning highly accurate Sanger-sequenced Chr3S pseudomolecules from O. sativa and O. glaberrima for orthologous transposable elements and their derivatives.
