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Results seem to suggest that the interaction between casein and carrageenan, that is well described for model systems, also takes place in sterilized dairy desserts and that the rheological properties are importantly affected by the exclusion effect of starch.
Results from other fungal infection model systems also suggested that multiple cell types can produce IL-17A (reviewed in [28]).
Depletion of Popdc1 or Popdc2 in the mouse and zebrafish model systems also results in severe cardiac arrhythmias [ 17].
There is unresolved controversy about whether direct carcinogenic effects of some oestrogen metabolites, which can clearly be demonstrated in model systems, also have a significant impact in women.
Two other recently developed model systems also minimize the incidence of non-CNS tumors by limiting causal genetic events to particular cell types.
Current efforts in the development of organotypic hepatic model systems also need to consider these key factors that dictate the expression of liver-specific phenotype in vitro.
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To investigate whether genes identified in this model system also show gene expression changes in Alzheimer's disease (AD) brain, we have also used quantitative RT-PCR to examine in post-mortem AD brain tissue transcript levels of αB-crystallin (CRYAB) and tumor necrosis factor-induced protein 1 (TNFAIP1), human homologs of genes found to be robustly induced in the transgenic C. elegans model.
It is suggested that the scenario found in the CHO model system also applies to the human transporter and that mislocalization rather than impaired functionality of G215R ClC-7 is the primary cause of the related autosomal dominant osteopetrosis type II.
Having shown a link between KRT23 expression and 14-3-3ε 14-3-3ε 14-3-3εe further hypothesized that Smad4 re-expression in our SW480 celocalizationtem (also showe to induce KRT23 expression) could have a similar efurthern thypothesizeds cellular localizathat of 14-3-3ε.
Thus, 184- hTERT-L9 cells provided a genomically characterized model system, also amenable to RNAi transfection and image-based, high-content screening, whereby we could replicate in vitro the fibroblast-dependent growth environment of mammary progenitor cells in order to investigate the signalling pathways involved in regulating mammary epithelial and progenitor cell growth.
As HepG2 cells express the wild-type form of the tumor suppressor p53 [ 13], this model system also allowed us to detect the effects of ISG15 on p53 and its downstream protein p21, both of which play the key regulatory roles in cell survival or cell death [ 14, 15].
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