The list of newly discovered SUMO substrates is expanding only recently in other model systems whereas none existed so far for plasmodium before this study.
Having established that apocynin and AEBSF have considerably different IC50 values and are ineffective in some NOX model systems, whereas VAS3947 consistently inhibited NADPH oxidase activity in all three cell lines with similar IC50 values, we considered VAS3947 as the most reliable NADPH inhibitor.
In both studies, the molecular mechanisms of the apoptotic pathway were analyzed by microarrays, but we used an in vivo model system of BM, whereas cancer-derived cells served as in vitro culture system for the study performed by Unoki and Nakamura [ 54].
A complete overlap between computer data and its experimental validation could hardly be expected since expression profiles were deduced from plants infected with a variety of different pathogens whereas our model system included a single plant virus.
The indirect cocultures confirmed the osteoblastic origin of VEGF-A in the coculture model system used in this study, whereas OEC monocultures did not show any VEGF-A secretion.
In our xenograft model system, wtEGFR was the main driver of invasion, whereas mutated EGFRvIII was lost after serial passaging.
The temporal model system shows rich dynamics including limit cycles and chaos whereas spatial model shows different types of patterns for population distribution.
In other words, in our model system, high affinity, self-reactive T cells are efficiently positively selected, whereas, low affinity, less "dangerous" clones, fall by the wayside.
In a model system of acquired resistance to letrozole, AEE788 partially restored sensitivity to letrozole, whereas rapamycin was not effective, suggesting that letrozole resistance and mTOR activation may not be connected in this model [ 43].
"We consider them a model system".
