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Cells of the immune system have many unique functions, but underlying similarities in signaling mechanisms and pathways make a well-defined model system useful.
Larval zebrafish are increasingly recognized as being a genetically and pharmacologically tractable model system useful in high-throughput screens for PD-associated phenotypes (Bretaud et al., 2004; Flinn et al., 2008).
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Studying vaporization of binary mixture liquid droplets as a model system provides useful information for understanding several engineering applications involving multicomponent systems.
The BHK model system, while useful in revealing the steady-state fingerprint of fragmented CFTR, might not be reflective of the situation in epithelia where the CFTR expression level is much lower.
In addition, the use of three in-vitro model systems proved useful for examining complementary aspects of the epithelial and mesenchymal states, namely the active transition between states, the terminal differentiation states, and the act of migration.
Model systems provide useful tools to assess the effects of established compounds in different clinical situations.
Animal model systems are useful to identify the functions of htt in the complex developing organism.
What sorts of model systems are useful and how do we decide if a model is predictive of human disease?
As in other complex diseases, model systems are useful for controlled experimentation, but often suffer from the problem of limited extrapolation to clinical studies.
Despite these biological differences, model systems are useful for studying signal transduction pathways important in tumor biology, of which mRNA expression, as measured by qPCR or using gene expression microarrays, is frequently used as a readout.
Drosophila as a useful model system is widely used in many fields of biological studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com