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A recent study using M. marinum infection of zebra fish as a model system, suggested the involvement of mmp-9 in the interaction of bacterial secreted proteins with the host epithelium contributing to early bacteria growth, local expansion and systemic dissemination [27].
The results for this model system suggested that focusing on specific complexes in other compartments could yield interesting results.
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Preliminary tests on a representative model system suggest that standard step size values used at present are lower than necessary for accurate sampling.
Numbers of the main bacterial groups were consistently higher than in an existing three-chemostat gut model system, suggesting the advantages of the new design in providing an environment for bacterial growth to represent the actual colonic microflora.
In instances where the knowledge base derived from the model system suggests that the adaptation has progressed extensively, more drastic measures to curb the impact can be initiated.
Extrapolation from an in vitro model system suggests that the concentration in the epidermis or papillary dermis (0.3 mM) by far exceeds the concentrations required to be antimicrobial (2.5 to 25 µM) and chemotactic in vitro (250 nM) as described previously by others [9], [39].
These experiments in a model system suggest that harvest-induced trait change may have important effects on nutrient dynamics and ecosystem processes.
This generic finding in our simplified model system suggests a pathway to a deeper understanding of more complicated mechanisms ongoing in living systems such as drug uptake where molecular interactions and solvent properties play a major role.
Moreover, these mutant viruses have been found to be 2-3 less less infectious than wild-type virus and significantly less transmissible in a ferret model system, suggesting that this substitution impairs NA activity and limits transmission ability.
The observations from this tumour model system suggest that before using tumour volume or weight as an index of therapeutic response, the relationship between the kinetics of tumour cellularity and tumour volume must be defined.
Pretreatment of astrocyte-enriched cultures with minocycline before A β application significantly reduced neuronal death in this model system, suggesting that the neurotoxic astrocyte-derived soluble factor(s) released in response to A β may be an inflammatory mediator.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com