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This model system revealed new insights into the role of Akt kinases in glucose transport and adipogenesis.
Gene expression analysis in this cellular model system revealed substantial amounts of Snail2 and E-cadherin mRNA, but very little Snail1 mRNA (Foubert E, Berx G, unpublished observation).
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Our experimental results using this model system reveal that the specialized ramified morphology of microglia as well as the quantitative dynamics of their motile processes are strongly influenced by retinal neurotransmission and are reciprocally regulated by different modes of neurotransmission.
In conclusion, our model system reveals that complete repair of a myocardial infarction is possible in the newborn mouse.
Preclinical study of the in vivo therapeutic effect of sequential combinations of topoisomerase I- and II-acting drugs in a murine tumour model system reveals that topoisomerase I mRNA and protein levels in the tumour decrease, whereas topoisomerase II mRNA and protein levels rise, after treatment with camptothecins (Eder et al, 1998) and topotecan (Liebes et al, 1998).
Ordureau, A. et al. Dynamics of PARKIN-dependent mitochondrial ubiquitylation in induced neurons and model systems revealed by digital snapshot proteomics.
Early studies using in vitro cell culture model systems revealed a contribution of Rac1 to cell cycle regulation [11] and in Ras-mediated transformation [12], [13].
Over the past years, studies based on in vitro model systems revealed several mechanisms that may contribute to diminished efficacy with PIs and acquisition of resistance.
Studies on animal model systems revealed that DHEA is a powerful inhibitor of mammary, prostate, skin, lung, liver, and thyroid carcinogenesis [ 4- 7].
Centrioles are complex structures, but work in several model systems revealed only a small number of conserved proteins to be important for centriole assembly.
Despite the differences in experimental protocols or bioinformatics analysis, current and previous studies using different T-cell apoptosis model systems revealed common GR targets potentially important in glucocorticoid-induced apoptosis.
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