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The present wound-healing model system provides a suitable invivo tool to test gene transfer strategies for human skin repair.
This model system provides typical process situations requiring ervo and regulatory control in the presence of load disturbance, noise, process model mismatch and deterministic chaos.
Overall, the HA model system provides a useful platform for the study of tumor cell responses to growth factors and for screening of anticancer drugs targeting these pathways.
This model system provides a unique opportunity for preclinical evaluation of safety approaches that limit CAR-mediated toxicity after tumor destruction in vivo.
Studying vaporization of binary mixture liquid droplets as a model system provides useful information for understanding several engineering applications involving multicomponent systems.
Furthermore, even though additional amino acid residues (outside of the 23-144 regiof of PrP) are also known to play a role in species barriers for prion transmissibility, mechanistic insight into cross-seeding barriers in the experimentally accessible PrP23-144 amodeld model system provides a conceptual framework for future studies with infectious aggregates formed by the full-length PrP.
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Harris, in his model system, provided that "the candidates should be permitted to designate the precincts which they wish to have recounted and to amend and add to the list from time to time".
Our method using transgenesis can be used to explore the function of regulatory and protein-coding sequences obtained from any extinct species in an in vivo model system, providing important insights into gene evolution and diversity.
The genomic resources developed to study X. tropicalis biology are crucial to explore amphibian physiology and genetics, this model system providing excellent characteristics for addressing key questions related to anuran metamorphosis and its associated regulatory processes.
Therefore, we believe that the methylation events identified in the in vitro model system provide potential markers for cervical cancer detection as well, which is underlined by their large overlap with methylated gene promoters found in cervical carcinomas.
BB and SW contributed equally to the manuscript, specified criteria for a model system, provided herbarium material, tissue, and DNA vouchers, generated capillary sequence data and drafted the manuscript.
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