Sentence examples for model system lacks from inspiring English sources

Moreover, the impact of mTOR inhibition on radiosensitization was independent of p53 status as, in contrast to LNCaP cells, the LAPC4 model system lacks functional p53 (van Bokhoven et al. 2003).

There is also evidence from a yeast model system lacking endogenous DNA methyltransferases and ectopically expressing mouse Dnmt3a and Dnmt3L that depletion of H3K4 methylation results in increased DNA methylation [ 65].

Many model systems lack species specific organized phenotype based gene sets to enable high throughput analysis of large molecular datasets.

Validating the relationship between regulatory plasticity and adaptive value is particularly difficult in non-model systems lacking well-established reverse genetic approaches.

Furthermore, in this mouse model system, mice lacking Exo1 lived significantly longer than control mice expressing Exo1.

Meanwhile, the system lacks accountability.

Experimental work in a non-model system that lacks standard genetic tools is challenging, so these experiments along with the data in E. coli provide a good means of assessing function.

The main insect model system Drosophila melanogaster lacks systemic RNAi and is therefore not well suited to screen for RNAi target genes [ 17].

To date, the conflictive interaction of malignant cells with the tumour microenvironment are insufficiently understood and functional model systems are lacking.

However, the Model-Based Design of actuation systems lacks methodologies and expressive simulation models that are suited to preliminary design, where key technical decisions are taken considering various design alternatives and few available design details.

Despite the progress made using the MCF10A model system, we still lack comprehensive knowledge of key genetic events that drive the progression of the MCF10A series of cell lines through the steps of immortalization, transformation, malignant tumor formation, and tumor metastasis.