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However, in our model system, increasing matrix stiffness did not increase ErbB2 activation (data not shown).
In the C6 cell model system, increasing cAMP levels activates PKA, stimulates IL-6 production, and consequently increases GFAP transcription via a PKA-CREB and JAK-STAT3 signaling cascade (Takanaga et al., 2004).
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Miller et al. (2001 , 2002 indicated that the presence of tungsten in an in vitro model system increased the toxicity of both nickel and cobalt in a synergistic manner.
Within this model system, increased Arg1 was the only marker able to positively discriminate an M2a phenotype at all time points.
Recently, the importance of U. maydis as a model system increased, as studies on the microtubule cytoskeleton in polar growth and mitosis revealed that important processes are conserved between U. maydis and mammalians.
With the advancement of computational systems and the development of model integration concepts, complexity of environmental model systems increased.
In model systems, increased expression of Ets-1 was found to be associated with enhanced angiogenesis and the invasive phenotype (Vandenbunder et al, 1994a, 1994b; Ito et al, 1998; Sato et al, 2000).
We agree that increasing the number of model systems increases confidence in the general relevance biological data.
That is, in our model system an increasing mutation rate decreases the fidelity with which each generation can pass along its traits (in this case just polymerase rate) to subsequent generations.
The honey bee is an important model system for increasing understanding of molecular and neural mechanisms underlying social behaviors relevant to the agricultural industry and basic science.
Similarly, ICAM-1 (intercellular adhesion molecules) enhanced T-cell receptor signaling and activated Th1 immune responses in the JEV model system by increasing the induction of CD4 Th1 cell subset and activating dendritic cells [ 85].
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