The development of novel embryo-derived model systems, combined with methods that examine chromatin status and chromosome conformation, led to deeper understanding of the process of Hox activation in the early embryo.
Model systems combining different defects were also explored, including a defect-anchored metal system, a bilayer graphene system and a grain-boundary system.
The Xenopus model system combines electrophysiological rigor with a cell type that does not express mammalian PC2, a protein shown to affect PC1 cleavage and expression of PC1 cleavage products [26], allowing a clear picture of any role PC1 cleavage products may have in regulating SOCE.
The optimization model consists of a simulation model of a solar-assisted drying system combined with an economic model.
We conclude that a multi-model screening system combining the use of cell cultures in vitro and the hDMD/mdx mouse in vivo could reduce potential risk of variation in efficiency between cell culture and in vivo and represents a more systematic approach for identifying AOs of high efficacy, thus better suited to meet the regulatory requirement for AO drug development.
In this study, a thermodynamic model of Organic Rankine Cycle (ORC) system combined with orthogonal design is proposed.
Hence, this paper focuses on energy and exergy analyses applied to the conventional aircraft environmental control system combined with the model-based design approach.
The development of prediction models using the cancer TNM staging system combined with the basic clinical covariates and microarray gene expression variables for identifying high-risk and low-risk patients for treatment recommendations has been an important goal in clinical oncology research.
Here, using Vibrio cholerae as our model system, we combine mechanical measurements, theory and simulation, quantitative image analyses, surface energy characterizations, and mutagenesis to show that mechanical instabilities, including wrinkling and delamination, underlie the morphogenesis program of growing biofilms.
In order to use the AP-1 bla ME180 CellSensor as a model system for combining targeted agents against components of a cancer-related pathway, we determined the dose-dependent response of the pathway to EGF stimulation.
