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Also many apolipoproteins (apolipoproteins A-I, A-IV, and E) are modulated in our model supporting this hypothesis.
Furthermore, intracellular accumulation of ATRA after incubation with 13cisRA and a delayed response to 13cisRA compared to ATRA is seen in both NBL and sebocyte cell lines, and in a human NBL xenograft model, supporting this hypothesis (Tsukada et al, 2000; Ponthan et al, 2001; Veal et al, 2002).
Substituting Tyr106, and also Tyr251, with Ala or Phe resulted in <6 fold changes in EC50 compared to wild type receptors, indicating that these residues also do not play important roles in the function of the receptor; these residues are facing away from the binding pocket in the <span class="lh">model, supporting this hypothesis.
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The Canadian model supports this kind of scenario.
The American (GFS) weather model supports this scenario.
The theoretical analysis using a mechanistic model supports this observation.
TL DR: If you need a lock that you can control from hundreds of miles away, make sure your model supports this.
Cerebral spinal fluid, interstitial body fluids and connective tissue surrounding veins, they conclude, could well have prevented collapse of the intracranial veins when Brontosaurus raised its head above 8 m, and their scale model supported this conclusion.
The implemented model supported this hypothesis.
The results from the diffusion model supported this view.
Findings from one experimental endotoxemia model supported this [ 8].
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