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The uracil permease Fur4 is an experimentally well-characterized model substrate of Rsp5.
OPN is a model substrate of Fam20C.
In an additional randomised crossover study, fulvestrant did not significantly affect the pharmacokinetics of an agent (midazolam) that is a model substrate of CYP3A4 (Table 2 > -wrap-foot>) (Lalght et al, 2003).
Recombinant Fam20C exhibitedibited greatly reduced in vitro kinase activity towards casein, ENAM (173 277), as well as osteopontin (OPN), an SCPP and model substrate of Fam20C, as compared to WT Fam20C.
Avicel purchased from Serva was chosen as the model substrate of wood-derived microcrystalline cellulose, and washed insoluble fraction of hydrothermally pre-treated wheat straw (WS) pre-treated in Inbicon, Denmark, as the lignin containing, industrially available lignocellulosic raw material.
Similarly, we found that compromised degradation of another model substrate of the proteasome UbV76-Val-βgal does not elicit toxicity in rad23Δ dsk2Δ mutants [ 12], indicating that the toxicity triggered by substrate accumulation may depend on the physiological function of the target protein.
Similar(54)
The impact on dark fermentation of seven carbohydrates as model substrates of lignocellulosic fractions (glucose, cellobiose, microcrystalline cellulose, arabinose, xylose, xylan and wheat straw) was investigated.
Here we explore the usefulness of the varied degree of hydrolysis towards these model substrates of FAEs to gain a more complete understanding of the relationships among fungal class, order, and family.
Subsequent work showed that deletion of RPN4 inhibits the degradation of several model substrates of the N-end rule and UFD (Ub fusion degradation) pathways, suggesting the involvement of Rpn4 in proteasomal degradation [3].
Detailed kinetics studies using model substrates of varying length will provide insights into the substrate specificities of these tailoring domains.
(A – C ) 12-bp model substrates of (A ) dsRNA (yellow); (B ) A-DNA duplex (pink); and (C ) B-DNA duplex (red).
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