Although the effect of flow was not studied in our patients, the model study indicates that overestimation should be higher at low flow.
Additionally, transgenic animal model studies indicated that tumourigenesis does not require gene amplification [ 18].
Laboratory and animal model studies indicated that zinc and iron compete for absorption in the intestinal lumen as they have similar physicochemical properties [ 33- 35].
Both kinetic analysis of AChE inhibition and molecular modeling study indicated that 49 was a mixed-type inhibitor, binding simultaneously to the catalytic active site and peripheral anionic site of AChE.
Modeling study indicated that the selectivity of our compounds to hMAO-B is determined by at least two residues, i.e., Ile 199 and Cys 172 (or corresponded Phe 208 and Asn 181 of hMAO-A).
Computer modeling and simulation study indicated the analogues had unique binding mode when forming CD1d/glycolipid/NKT TCR complex, comparing to original α-GalCer.
Animal model studies indicate that hypercholesterolemia increases neutrophil counts and that neutrophils infiltrate arteries in the early stages of atherosclerosis[35].
Model studies indicate that this configuration favors the targeted delivery of NaCl to loop bends, where a favorable gradient, sustained by urea absorption from collecting ducts, promotes NaCl absorption.
Model studies indicate that nonlinear interactions contribute to the TDT preferably at low and midlatitudes (Smith and Ortland 2001; Huang et al. 2007).
In vitro and animal model studies indicate that high and disseminated viral replication is an important factor in disease pathogenesis [4] [7].
