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Analysis of the enzyme 3D model structure showed that the amino acid residue Asp98 may directly affect the pH-profile of enzyme activity since it is located at the distance of hydrogen bond formation from Glu203 that plays the role of a general acid in catalysis.
The PatchDock' model structure showed the largest interaction surface.
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The hybrid model structure shown in Fig. 4B was adopted to identify the network, Fig. 4A.
For each of the 18 models, the model structure shows the factors and interaction terms included in the model.
Its basic model structure, shown in Fig. 1a, consists of a single linear filter " L" that converts a stimulus s x, t), which can depend on time t and spatial coordinates x, into the filter output y(t).
The model structures shown in Figure 5 are those that were explored and found to best fit the diffraction data.
Based on the modeling structure shown in Figure 2, the contrast agent concentration in bone marrow and muscle can be formulated as the following differential equations: (1) d C m (t ) d t = K trans . m · C p (t ) − (K trans . m v e. m ) · C m (t ) (2) d C BM (t ) d t = K trans .
Nonlinear dynamic analysis of the model structure shows that the dampers installed using the proposed procedure are effective in restraining the building displacement within a given target performance limit state.
The LexA Pa model structure shows both positions to be relatively solvent-exposed, forming few specific contacts with the surrounding active site.
The Tud7-11 model structure shows that all sDMA-binding sites are well spaced and accessible, with the sDMA-binding sites of Tud7, Tud9 and Tud11 located on one side of the protein surface (Supplementary information, Figure S1H).
The practical parameter identifiability analysis performed on the selected model structures shows, as expected, parameter identifiability problems.
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