Exact(6)
In an in vitro hypoxia model, stimulation of tubular epithelial cells with SCF activated survival signaling and decreased apoptosis.
On a cellular basis in an experimental cell culture model, stimulation of trigeminal ganglia neurons with potassium chloride, capsaicin or a cocktail of inflammatory mediators used to mimic neurogenic inflammation resulted in an elevated CGRP release in these cells.
In the CIA model, stimulation of DCs with TNFα generates DCs with a strong suppressive capacity.
However, in our model, stimulation of the migratory phenotype was observed without irradiating the cancer cells.
In our experimental model, stimulation of the lbpva55 cell line with 10 ng/ml IL-1β resulted in upregulation of mRNA and protein expression of collagenases MMP-1 and MMP-13 and the stromelysin MMP-3.
In our model the observed phenomenon of reduction in plasma renin activity emerges as a property of the integrated computational model: stimulation of the baroreflex and associated drop in sympathetic tone is predicted to result in a drop in renin production even with the long-term drop in mean pressure.
Similar(54)
The increase in dBP following sunitinib treatment was described using (i) an indirect response model with stimulation of Kin or (ii) the alternative model with inhibition of kout.
Based on this, we predict cAMP levels of other drug combinations, illustrating the capabilities of the full model: Simultaneous stimulation of AC and inhibition of PDE3 is modeled by combining Iloprost (2, 5 and 20 nM) and Milrinone (10, 50 and 200 μM; Figure 5B) or Cilostamide, respectively.
In the model, prolonged stimulation of SNc cells by an overactive STN leads to an increase in 'stress' variable; when the stress in a SNc neuron exceeds a stress threshold, the neuron dies.
In this model, electrical stimulation of the motor cortex of rats, along four pairs of a microwire electrode array, results in an observable seizure with quantifiable electrographic duration and behavioural severity.
Thus, intranasal application of 200 μg capsaicin is a potent model for stimulation of TRPV1 positive nociceptive neurons of the first trigeminal branch.
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