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Nevertheless, a rough estimation of model specificity was indirectly and tentatively estimated by further independent techniques (i.e., chemical and histological examinations) described in the Materials and methods section.
By contrast, the expectation-variance model specificity was constant as a function of the study year, study month, and the day of the week.
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The x axis of the ROC plot represents the false-positive error rate, which is equal to 1 minus the model specificity, where the model specificity is the class prediction accuracy of nonignitions.
Furthermore, the proportion of men who died in each of the groups (Additional file 1: Table S1) showed a modest decrease in sensitivity of the PSA-gene model compared to the PSA-Gleason model; however, specificity was similar, thus prompting future efforts to assessment of DNA methylation in body fluids.
For the male classification model, the specificity was 90.3% and the bootstrapped sensitivity was 51.0%.
For the female classification model, the specificity was 90.0% and the sensitivity was 37.1%.
As in the murine model, H4R specificity was established by gene silencing that abolished most of the anti-proliferative effect of CB on CD34+ cells stimulated with growth factor cocktail (Fig. 6D).
The model for specificity was more complex.
The positive predictive value was then estimated by taking the cut-off score of the AUC of the final model where specificity was 0.90.
The only significant difference was for NTproBNP ≤300ng/L; when adding prevalence differences into the model the specificity was significantly higher at 0.93 (95% confidence interval 0.84 to 0.97, P<0.01).
The protein profiles could distinguish between separate infection models, although specificity was moderate to low.
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