The exoniphy program identifies evolutionarily conserved protein-coding exons in a multiple alignment using a phylogenetic hidden Markov model, a statistical model that simultaneously describes exon structure and exon evolution.
The exoniphy program identifies evolutionarily conserved protein-coding exons in a multiple alignment using a phylogenetic hidden Markov model phylo-HMM [ 23], a statistical model that simultaneously describes exon structure and exon evolution.
This program, designed by Siepel and Haussler, identifies evolutionarily conserved protein-coding exons using a phylogenetic hidden Markov model, which simultaneously describes exon structure and exon evolution [ 16].
In conclusion, a model that simultaneously described azithromycin concentrations in blood, PBMCs, and PMNs over time was developed with good model performance.
Given this is the first population model to simultaneously describe free and total teriflunomide concentrations, it may be used within pharmacokinetic-pharmacodynamic models to assess the concentration effect relationship.
Based on the assumption that the stochastic demands of the retailers are normal distributed, a non-linear mixed integer programming model that simultaneously described the inventory decision and the facility location decision is presented, in which the objective is to minimize the total cost that including location costs, inventory costs, and transportation costs under the certain service level.
A single-dose study in 20 healthy adults was conducted, and nonlinear mixed effects modeling was used to simultaneously describe azithromycin concentrations in blood, PBMCs, and PMNs (simultaneous PK model).
A new 3D continuum model is developed to simultaneously describe cracks and dislocations in materials undergoing finite strain deformations.
A PopPK model was built to simultaneously describe unbound and total vismodegib plasma concentrations.
By considering seasonality as a deterministic component to be estimated jointly with the trend through Nonlinear Least Squares methods, we have developed two extensions of the Guseo Guidolin model that are able to simultaneously describe trend and seasonality.
