The model group exhibited significantly highlighted regions of Gd-DTPA after post-contrast at the corresponding areas and time points compared with the sham group (P < 0.05).
The AREs in the linear model exhibited significantly higher values than those in the nonlinear model (Additional file 8: Figure S1, P-value<0.001).
The alternative models all exhibited significantly poorer fit than the baseline model.
If the haplotype model had exhibited a significantly better fit then there would have been indication that other, linked, un-typed, SNPs were responsible for the association [ 27].
In addition, γ-secretase inhibitor-treated xenograft models exhibited significantly slower osteosarcoma growth.
Nevertheless, arteries from both models exhibited significantly increased expression of caveolin-1, which binds a number of important signalling molecules including endothelial nitric oxide synthase [ 27], and significantly decreased expression of Rgs2 and Rgs5, which terminate the signalling of the G proteins Gq and Gi/o [ 28].
As shown in Fig. 5A, a linear regression model exhibited a significantly high R value (0.871; P<0.05) using the enter selection method with all factors entered.
We not only demonstrated that the histone and nonhistone models had better predictive performances than the mixed model but also showed that our models exhibit significantly improved prediction sensitivity, specificity, accuracy, and MCC of lysine acetylation sites compared to previous approaches.
It is further demonstrated that the original and modified model exhibit significantly different response under seismic excitation.
For each parameter of interest, a two-sample Kolmogorov-Smirnov test [28] was conducted to determine if the distribution of that parameter within the screened models exhibited a significantly shifted distribution (with 95% confidence) when compared to the original ensemble of 1500 models.
