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Efficacy study of CLX-103 in acute dextran sodium sulfate (DSS) mouse colitis model showed improved potency measured as Disease Activity Index (DAI) and histological scores in the colon as compared to sulfasalazine.
Secretable GAA showed improved therapeutic efficacy and lower immunogenicity compared to nonengineered GAA.
(51) This ability to bypass the endosome may show improved therapeutic efficacy in drugs that are active within the cytosol.
Pegylated liposomal doxorubicin has shown improved therapeutic efficacy when combined with radiotherapy in several animal studies and clinical trials.
Two novel risk models were developed showing improved predictive ability.
Efficacy studies of disease management that include SMS have shown improved patient satisfaction, knowledge, self-efficacy, coping, and behavior but have less consistently shown improved physiological outcomes or functional status (3, 4).
Preclinical in vivo efficacy data have shown improved antitumour activity of PEP02 over the equivalent dose of free irinotecan in multiple established human tumour xenograft mouse models, including brain, colon, and pancreatic cancers (Hann et al, 2007).
Risk models produced using penalised regression generally show improved calibration, and could also show improved discrimination.
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We also show that this dual-targeting drug has significantly improved efficacy over drugs that have single targets in many cancer cell lines and various cancer mouse models.
Moreover, the compound has improved efficacy in a hedgehog/smoothened signaling mouse pharmacodynamic model.
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