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In contrast to the toxic-RNA gain-of-function model, several studies have revealed a role for ZNF9 in DM2.
In further support of this model, several studies have shown that K protein can alter rates of transcription (Michelotti et al, 1996) and translation (Ostareck et al, 1997).
Consistent with this model, several studies demonstrated that alterations in satellite cell proliferation and/or differentiation have an impact on muscular dystrophy [78 81].
27 Similar to the results obtained in the current in vivo studies of an early-stage type 1 diabetes model, several studies have demonstrated an enhanced SGLT2 expression in the kidneys in both type 1 and type 2 diabetic animal models.
Using this model, several studies have clearly demonstrated cellular neuroprotective effects on dopaminergic cells with compounds such as monoamine oxidase B inhibitors, vitamin E, the mixed lineage kinase inhibitor CEP-1347, the anti-excitotoxic agent riluzole or coenzyme Q10 (Perry et al., 1985; Benazzouz et al., 1995; Beal et al., 1998; Saporito et al., 1999; Andringa et al., 2003).
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Supporting these models, several studies in the United States have demonstrated concurrency and unawareness of partners' concurrency to be risk factors for transmission of syphilis and viral STI's [12], [13].
Moreover, in animal models several studies establish an inhibitory role of retinoids in breast cancer.
Mainly using amputation and genetic ablation models, several studies have characterized differential expression responses at different times after injury based on microarrays or in situ hybridization techniques [ 31].
Despite the promising effects of TKI in AD models, several studies previously reduced amyloid plaques in transgenic mice, but failed to halt AD progression in humans.
Using various cancer cell models, several studies revealed different contributions of TRAIL DRs: DR5 contributes to TRAIL-mediated cell death in colon and breast cancer cell lines; however, chronic lymphocytic leukemia cells exhibit apoptotic signaling via DR4.
For acute injury models, several studies have demonstrated decreasing HA concentration in synovial fluid [ 29- 32], but some reports did not show any relation to serum level [ 22, 30].
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