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The key comments were regarding general clarity in the main text, particularly regarding our analysis and interpretation of FRAP experiments, as well as requesting more detail on the model set up and equations.
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We have tried to work out how the model is set up and what the parameters, rules and equations are (as shown in the first paragraph), but have not succeeded.
The model set up by Mosley and Chen has later been adapted to fit specific areas, for example HIV/AIDS (23), neonatal health (24), and maternal mortality (25), and the framework here presented is a further adaptation for the analysis of neonatal mortality risk factors (Fig. 1).
Therefore, a divide and conquer strategy is adopted, i.e., first develop a conceptual low-complexity model, set up the optimization problem and then use the obtained knowledge during the optimization of more complex models.
But Friendster's computer systems couldn't keep up with the explosive growth (reportedly due to the complexity of the security model set up to control connections, privacy and authenticity of users) so MySpace was hot on the heels and swept up the market in a very rapid ascent.
As variability is likely to exist in primary endothelial cell isolation yields and model set up, it may be beneficial to conduct an optimization study, such as the one presented here, prior to applying the model.
The model set-up and the environmental test conditions are described in more detail in [8].
As such it allows for product and region specific assessments of GHGs and mitigation potentials to be made without the need for expert knowledge or for lengthy model set-up and calibration.
MV developed the coupled model set-up and ran the model.
KMb coordinated the experimental design, model set-up and analysis, and co-drafted the manuscript.
The result of the analysis is an assembly of system models, denoted the Worst Case Definition (WCD) model, to set up and evaluate the conditions of multi-dimensional risk identification and risk quantification.
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CEO of Professional Science Editing for Scientists @ prosciediting.com