The flexible model revealed more significantly activated voxels, which resulted in more activated brain regions concordant with the EEG focus (26 vs. 16).
When few pumping tests with sparse monitoring intervals are available, the incorporation of accurate or simplified geological information into geostatistical models reveals more details in heterogeneity and yields more robust validation results.
Although the odds ratios for the incidence and worsening models are of similar magnitude, the confidence intervals of the point estimates for worsening models are more narrow than that for incidence models, revealing more precise estimates – which may be due to the use of a larger analytical sample than one limited to a subset of those free of disability at baseline.
Source data for Figure 4. DOI: http://dx.doi.org/10.7554/eLife.00288.022 10.7554/eLiFigure88.023 Figure 4 figure supplement 1. Continuous sampling of spatial model output reveals more accurate measures of episode characteristics.
Compared with the previous models, the proposed model can reveal more biological sense.
Moreover, the kinetic parameters introduced in the proposed model can reveal more biological sense than previous models can do.
In short, the degree of genome streamlining observed could be influenced by model choice; more complex models may reveal more nuanced patterns of genome expansions and contractions.
The developed model has revealed more dynamic battery behaviors related to the variation of the microstructure such as particle shape, tortuosity, and material composition while the corresponding result from P2D shows a monotonous change within different structures.
We know that miRNAs play significant roles in genetic regulatory networks, and our future work will incorporate miRNAs into our model to reveal more hidden mechanisms of HCC.
More comprehensive analyses of the C. albicans phenome, and more refined analyses of C. albicans virulence, for example using competition assays or specialized infection models, might reveal more subtle effects on virulence that relate to observed changes in gene expression in vivo.
