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For further assessment and validation of the logic of the model structure and outputs, reality checks and extreme cases were tested to assess if the model responded appropriately and assist in the design of baseline scenarios (see Technical Report (ibid).
iPSC-ECs in the sprouting model responded appropriately to several reference pharmacological angiogenesis inhibitors of vascular endothelial growth factor, NF-κB, matrix metalloproteinase-2/9, protein kinase activity, and β-tubulin, which confirms their functional role in endothelial sprouting.
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Such models respond appropriately to pharmacological challenge, particularly for LQTS and potassium or calcium channel blockers.
The findings have implications for clinical care, prevention and screening, for example, responding appropriately to the known low uptake among South Asian populations of bowel screening might benefit from modelling of cost-effectiveness of screening, given comparatively low cancer rates.
Validation depends on selecting model parameters consistent with the known epidemiology of TB transmission and ensuring that the model responds appropriately to these parameters.
The wife called all the appropriate authorities, who responded appropriately.
Verizon maintained that it had responded appropriately.
The students responded appropriately, with yawns and idle doodling.
The press also responded appropriately, with universal disgust.
"The police responded appropriately," said Inspector Edward Mullen, a police spokesman.
No, Mr. Greenspan said, the Fed had responded appropriately.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com