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Our work reports the creation of the first patient-derived MPNST orthoxenograft model resource available for preclinical testing.
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Depending on the fault model and the resources available, different abstractions can be employed for representing architectural issues related to fault tolerance.
Most algorithms and model resources in OpenTox are available in multiple representations.
As first it was proposed to complete the dialectic of in vivo - in vitro model adding in silico model to increase the resources available to study a complex phenomenon as the physiology of male gamete.
This process, referred to as parameter sweep, can be performed in parallel over a large number of computers and would seem to match nicely with the Cloud model of (apparently) infinite resources available on demand.
One of the advantages of computational models is that they can be exploited to obtain information regarding multiple functional parameters throughout the three-dimensional (3-D) volume of the tissue, with resolution limited only by the level of detail represented in the model and the computational resources available to solve it.
The time t should be discretised to ensure that the model is solvable with the computing resources available (for example the time step can be set as 15 min when the islanding period is 5 hours).
In the last 15 years, there has been a proliferation of genomic resources available for model organisms.
Genomic resources available from model legumes are hence potentially extremely valuable for the development of genetic tools in white clover.
Selecting the appropriate modelling approach for a given problem involves a number of factors including a researcher's judgement of the time available for model development and the computational resources available.
The motivation for implementing ZFNGenome, summarized in Figure 2, was to create a user-friendly interface between two valuable open-source genomic resources: i) established genome browsers, with associated genomic DNA sequences, annotations and other resources available for model organisms; and ii) ZFN design software tools and experimental reagents made available by the Zinc Finger Consortium.
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