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Ricken et al. (2010) developed a poroelastic model of the liver tissue and combined this with a model of the development of sinusoidal orientation to model remodeling of the liver tissue after injury.
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We believe that this is a key mechanism of how bone, at certain loading frequency, strain, strain cycle, and strain gradient, leads to load-induced bone modeling, remodeling, and maintenance.
We previously developed a load-adaptive bone modelling and remodelling simulation model that can predict changes in the bone micro-architecture as a result of changes in mechanical loading or cell activity.
Thus, IBRA allows analyzing a CAD model without remodeling and meshing, even for complex geometries.
Our group has been investigating the role of BMPs in an animal model of remodeling arthritis [ 17, 18].
In the case of normal bone the model views remodeling as stable regular oscillations in a spatially heterogeneous microenvironment.
There are many theories regarding bone self-regulation, including the degree of strain regulation on bone modeling process, time-dependent bone modeling, and remodeling processes [ 27].
Modeling and remodeling are successful during growth, not adulthood.
This chapter deals with modeling and remodeling of the bone.
However, modeling and remodeling of BMP-induced bone have rarely been discussed.
However, it remains to be shown how microgravity affects the expression of genes involved in modeling and remodeling of bone material in vivo.
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