Though the heterotrimeric G-proteins signaling system is one of the best studied in eukaryotes, its provenance and its prevalence outside of model eukaryotes remains poorly understood.
This large excess in COX capacity, also defined as COX reserve capacity, has been described in different tissues and models, but remains poorly understood (46– 46).
Furthermore, while there is growing evidence that psychiatric disorders including autism [24] and schizophrenia [25] may be associated with de novo CNVs, the contribution of common CNVs to behavioral variability in model organisms such as mice remains poorly defined.
While the behavioral phenotype of the CLN6 mice remains poorly characterized, this model displays pathological features such as brain atrophy and inflammation (Thelen et al., 2012b), closely resembling the disease in humans (Bronson et al., 1998).
Although garcinol has been shown to have cancer chemopreventive properties in animal models [ 30], its biological action remains poorly understood.
However, while substantial knowledge is available for several model strains, the diversity of cyanobacterial metabolism remains poorly understood.
Therefore it remains poorly understood and poorly modeled, as even archipelago-scale differences in carbon cycles are not accounted for and quantitative impacts on calcification rates remain poorly resolved [2], [50], [52].
The genomic architecture of adaptive traits remains poorly understood in non-model plants.
The network of miRNA-mRNA interactions in animal models of BPD has not been described and remains poorly understood.
Drosophila neural progenitors (neuroblasts) have been an excellent model for studying self-renewal and differentiation, but quiescence remains poorly understood.
