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The perfect experimental model recapitulating the main pathological characteristics of AD has yet to be engineered, but available models address a number of pathological AD features allowing to translate human markers to mice.
More strikingly, in a mouse model recapitulating the retinal degeneration affecting SCA7 patients, the retinopathy correlated with a global repression of genes specifically involved in photoreceptor function and morphogenesis, suggesting an alteration of the neuronal differentiation program [15], [16].
To answer these questions, we developed a larval zebrafish model recapitulating the locomotor deficits that are observed in human manganism.
The regulatory effect by the core set is propagated through stoichiometry throughout the model, recapitulating the experimentally observed changes.
We evidenced the occurrence of fibrosis in vivo using a mouse model recapitulating the aggressive course and liquid phase of peritoneal PEL 25.
Thromboplastin triggers the clotting cascade through the extrinsic pathway via complexation of tissue factor and factor VII, and blood clots embolize to the lungs in this model, recapitulating the life-threatening clinical condition of pulmonary embolism (PE).
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Furthermore, our xenograft model recapitulates the human condition with respect to CEA expression.
The model recapitulates the biological complexity of glycosylation, but does not require user-provided kinetic information.
Consistently, our WS stem cell model recapitulated the upregulation of IL-6, a phenotype of SASP, in the medium of WS MSC cultures (Zhang et al., 2015).
The model recapitulates the G2 delay observed in the biological response to varying levels of a DNA damage signal.
The model recapitulated the positive feedback between Her2 induced MAPK activation and androgen action.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com