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Indeed, HER2/HER3 appears as a resistance mechanism to PI3K inhibition and the model recapitulates several resistance mechanisms observed in HER2+ breast cancer (Table 4).
This model recapitulates several important features of the human airway epithelium [ 21].
This model recapitulates several of the neurological features of Lowe syndrome.
This model recapitulates several of the neurological features of Lowe syndrome including increased susceptibility to heat-induced seizures and white matter lesions.
Therefore, disease pathogenesis in the pristane model recapitulates several key features of human SLE, including kidney pathology, IFN-I pathway activation, autoantibody production, and induction of apoptosis.
The group report that this in vivo model recapitulates several of the canonical features of mammalian candidiasis and displays gene expression patterns that confirm recent in vitro observations.
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This model recapitulated several aspects of ALS pathology, including locomotor dysfunction and reduced survival.
These data obtained in a novel rat model recapitulating several relevant features of the human condition speak in favor for the use of immunosuppression in clinical trials using allogeneic tissue.
Human neural progenitor cells, human stem cell lines, and human cord blood derived stem cell models recapitulate several key neurodevelopmental events, including differentiation of precursor cells into neurons and glia and the formation of neural networks.
These models recapitulate several phenotypes observed in humans, including bowing of the tibia, impaired bone strength and short stature (de la Croix Ndong et al., 2014, 2015; El Khassawna et al., 2012; Kolanczyk et al., 2007; Kossler et al., 2011; Rhodes et al., 2013; Schindeler et al., 2008; Wang et al., 2011; Zhang et al., 2011).
Importantly, this GBM model frequently recapitulates several key features of the human disease that are lost in conventionally-cultured glioma cell lines, including retention of markers such as EGFR overexpression and a tendency for the orthotopically-implanted cells to invade throughout the mouse brain [38] [40].
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