Mutant VCP knock-in animals provide a new model recapitulating key pathological features of ALS, which may yield insights into pathogenesis of both familial and sporadic forms of human disease.
The phenotypes of these models recapitulate key features of human psoriasis, but differ with respect to the initiating (biochemical) events.
Although, Mecp2 mutant mouse models recapitulate key characteristics associated with RTT patients including an initial phase of apparently normal development followed by severe neurodevelopmental dysfunction, there is evidence that mouse models are an underrepresentation of the human condition (19– 219.
Thus, the αB-crystallin R120G knock-in mouse model recapitulates the key symptoms of human hereditary myopathy and cataract disease pathology.
Therefore, disease pathogenesis in the pristane model recapitulates several key features of human SLE, including kidney pathology, IFN-I pathway activation, autoantibody production, and induction of apoptosis.
Cell death in the Drosophila model recapitulates a key feature of disease observed in mouse diabetes caused by the same C96Y mutation in Ins2: the dominant loss of insulin-secreting β-cells (Kayo and Koizumi 1998; Wang et al. 1999).
A liver model that recapitulates key features of hepatic sinusoids is a potentially powerful medium for obtaining comprehensive knowledge on metabolism, detoxification and signaling pathways.
We hypothesized that mast cells mediate pelvic pain directly and examined pain behavior using a murine model that recapitulates key aspects of IC.
In summary, these results indicate that the layered rLSEC-PEM-hepatocyte model, which recapitulates key features of hepatic sinusoids, is a potentially powerful medium for obtaining comprehensive knowledge on liver metabolism, detoxification and signaling pathways in vitro.
