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Noticeably, chondrocytes of OA model rats showed a punctuate LC3 pattern.

All the ST model rats showed typical behavioral features of PD, such as back hunching and stiffness, face-washing behaviors, bradykinesia, or hypokinesia.

One month later, model rats showed significantly more deactivation on both sides of the amygdalohippocampus than control rats.

In this model, rats showed no significant recovery of vestibular dysfunction after termination of exposure at 13 weeks, in accordance with the extensive HC loss observed in the sensory epithelia (Llorens and Rodríguez-Farré, 1997).

In our experiment, model rats showed low percentage of SP value at >75 %; XSLJZD-induced increase in SP percentage corresponded to the improvement of the appetite of rats with FD.

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In this immuno-flap model, DC-treated rats showed significant suppression of tumor growth beneath the flap.

The well-established Complete Freund's Adjuvant (CFA) model in rats shows symmetry of joint involvement after 2 4 weeks, depending on the site and concentration of CFA injection (Donaldson et al., 1993; Decaris et al., 1999).

After one month, model rats also showed a significantly less total distance travelling (20.7%) and significantly fewer rearing events (23.8%) than control rats (Z = −2.062, P = 0.039. Figure  2D; Z = −2.072, P = 0.038, Figure  2E).

Experimental acute lung injury model of rat showed that local lung angiotensin II was involved in the pathogenesis of disordered coagulation of PAI-1 production in VILI [ 11].

In vivo study using acetic acid induced colitis model in rat showed that ulcers in curcumin loaded microsponges treated group were recovered up to a good extent as compared to control group while in pure curcumin treated group the healing was mild.

An experimental model of streptozotocin-induced diabetic rats showed that febuxostat improved endothelial dysfunction via attenuating oxidative stress by XO inhibition [ 51].

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