After the 30 days administration, the model rats with blood stasis were established by being placed in ice-cold water during the interval between two injections of adrenaline hydrochloride (Adr) and subcutaneously injected with Adr (0.8 mg/kg).
Zhao et al. [ 8], using model rats with fimbria-fornix transaction (FFT), demonstrated the neuroprotective effect of CIG.
Very recently, we have reported that the oral administration of madecassoside improves the memory loss of AD model rats, with concurrent inhibition of Aβ1 42 fibrillation [ 36].
To elucidate potential mechanisms of apoptotic induction in this tumour model, rats with subcutaneously implanted tumours were treated with vehicle (I), castration+vehicle (C) or castration + 50 micrograms of oestradiol benzoate per day s.c. (C + E2).
Our study showed that in model rats with myocardial ischemia, the fatty acids transportation pathway was down-regulated, illustrated by decreased expression of FATP which uptakes free fatty acids from circulation.
This study showed that in model rats with myocardial ischemia, the level of "good" lipoprotein HDL was down-regulated, while the level of "bad" LDL was increased by 98.3%.
The type 2 diabetic rats were selected for the experiment after conducting an oral glucose tolerance test (OGTT) and only the diabetic model rats with blood glucose levels of 8 12 mmol/L under fasting conditions were selected for the experiments [ 12].
In a more chronic inflammation model, rats with adjuvant-induced arthritis displayed sustained induction of mPGES-1 by immunohistochemistry in the brain vasculature and the paraventricular nucleus of the hypothalamus [ 20]. mPGES-1 null mice did not generate fevers in response to peripheral LPS injection but did become febrile after intracerebroventricular PGE2 injection [ 21].
Involvement of nitric oxide (NO) in the pathophysiology of human African trypanosomiasis (HAT) was analyzed in a HAT animal model (rat infected with Trypanosoma brucei brucei).
