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In the recently proposed framework for model qualification of physiological models, the first step frames the project questions and the project team agrees on the use of the model inferences for the decision making.
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As a second level of model qualification, we tested the sensitivity of the system-specific parameters for both models (EPIC 1 and EPIC 2).
The level of model qualification is dependent on the question being addressed.
The objective of model qualification is to examine whether the model is suitable for the proposed applications.
A schematic overview of the model qualification is provided in Figure 5.
Details of the flight model qualification test program are presented.
In addition, regulatory acceptance of systems pharmacology model qualification is needed to ensure that integrated knowledge can assist in model-informed trial design and in extrapolations beyond the observed data range.
For plasma PK profiles and urinary metabolite ratios, model qualification was performed by comparing population mean or individual values of the observations with the model predictions.
Model qualification.
A chamber for testing solar cells and other devices in a simulated space environment, and the integration and tests of two engineering models for qualification of space technology processes are described.
These findings can be considered a first step towards model validation and qualification of this osteoporosis model, which will be further elaborated by also applying the model to other therapeutic interventions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com