Sentence examples for model qualification in from inspiring English sources
CoSMoS, the principled design framework used in the development of ARTIMMUS, for example, shares many key features with the methods for physiological model qualification in drug discovery proposed by Friedrich and Savic.
A schematic overview of the model qualification is provided in Figure 5.
Merck's implementation of quantitative and system pharmacology in drug development focused on enabling key decisions through rigorous prioritization of opportunities, timely execution, influential communication, adequate model qualification, and securing team/management buy-in and funding.
In the model qualification step, simulated P1NP and CTX were consistent with changes in the turnover markers from three clinical trials with romosozumab and two clinical trials with blosozumab (Supplementary Figure 3).
An important issue in this regard is that model qualification by regulators is not only model validation per se but an evaluation of the modeling and simulation approach as an integral part of drug development.
In the recently proposed framework for model qualification of physiological models, the first step frames the project questions and the project team agrees on the use of the model inferences for the decision making.
Details of the flight model qualification test program are presented.
Model qualification was performed by comparing clinically measured SLD with those predicted by the model, evaluating the uncertainty in parameter values, and using the model to perform a simulation of two sets of 10,000 virtual patients.
JM created the methotrexate population pharmacokinetic model, provided model qualification and created the forecasting algorithm.
The identified helium-cooled lead-lithium and pebble-bed breeder blankets accidents analyses uncertainties and results obtained in their assessment both in models qualifications and applications to three selected accident scenarios are reported.
