Sentence examples for model proteins including from inspiring English sources

First, we generated [S]-methionine-radiolabelled nascent chains derived from different model proteins, including a truncated variant of isocitrate dehydrogenase (ICDH 1 410) and a gene fusion harbouring three copies of the folding deficient m10 variant of the α-spectrin SH3 domain (Blanco et al, 1999; Hoffmann et al, 2006).

The Human Proteome Project aims to create assays for all human and model organism proteins, including the myriad protein isoforms produced from the RNA splicing and editing of protein-coding genes, chemical modifications of mature proteins, and protein processing.

In a classic model, Giα proteins including Gi1α, Gi2α and Gi3α are important for transducing signals from Giα protein-coupled receptors (GiαPCRs) to their downstream cascades in response to hormones and neurotransmitters.

In multibiomarker predictive models, 3 proteins including HMMR, SIAH2, and SMAD4 were consistently represented among the top 2, 3, 4, and 5 most predictive biomarkers, and a signature comprised of these proteins best predicted BF at 3 and 5 years.

Maximum likelihood tree (JTT + IGF model) of selected proteins including UT family members.

Physics-based energy functions are expected to be globally valid for modeling interactions between proteins, including the non-native states.

Models of proteins include: neuronal SNARE core complex (PDB entry 1SFC), complexin/SNARE complex (PDB entry 1KIL), endosomal SNARE core complex (PDB entry 1GL2), and synaptotagmin/SNARE complex.[9], [10] Hydrogen atoms were added to the heavy atoms by PDB2PQR.[47] Partial atomic charges and atomic radii were assigned to each atom using a CHARMM parameter set.

Using Shigella flexneri 2a as a model, we identified total 823 proteins, including 187 hypothetical proteins.

IMCs in our model also secrete M2 marker proteins including YM1, arginase-1, MRC1 (soluble CD206) and legumain (Luo, 2006; Biswas & Mantovani, 2010; Murray & Wynn, 2011) (Supplementary Table S1) and promote tumour cell growth in vitro and ex vivo (Fig 3).

Based on prevailing models, Type 2B mutant pVHL proteins, including R167Q, are predicted to disrupt VBC complex formation by eliminating Elongin C binding to pVHL [13], [27] [30].

This study provides a framework for further investigation into the role of ER stress in ALS pathophysiology, particularly as it has emerged as an important factor in models involving other ALS-related proteins, including TDP-43 and FUS.