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Meanwhile, crystallins have been taken as model proteins in the protein folding field for a long time.

Two biotherapeutic protein molecules, granulocyte colony stimulating factor (GCSF) and Transtuzumab were selected as model proteins in this study.

We show that it is possible to couple metadynamics and Monte Carlo algorithms to obtain the free energy of model proteins in a way which is computationally very economical.

An additional approach to gain insights into the properties of amino-acid radicals is to synthesize de novo designed model proteins in which the redox chemistry of these species can be studied.

By improving the ELP method, and subsequently incorporating the neighborhood strategy with the pull-move set into the improved ELP method, a heuristic ELP algorithm is proposed to find low-energy conformations of 3D HP lattice model proteins in the discrete space.

Interestingly, Hauri and colleagues [11] have shown, using model proteins in HeLa cells, that Sec24 isoforms exhibit selective binding preference for some export signals and a number of export signals are recognized in a redundant fashion by two or more of the Sec24 isoforms.

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His-tagged cytochrome c oxidase (CcO) is used as a model protein in this study.

Therefore, Cyt c was selected as a model protein in this work, in order to study the main effects on the stability of noncovalent protein complexes.

Bovine serum albumin (BSA) can be used as a reference (model) protein in which its properties are compared with other proteins.

Pure MBP-intein-CBD has been used as model protein in adsorption stages on amylose affinity membranes.

Due to their wide hydrophobic, hydrophilic, anionic, and cationic properties, BSA has been extensively used as a model protein in many fields including drug delivery [25], biomimetic mineralization [26], nanomaterial synthesis [27, 28], surface modification and intermolecular interaction [29], etc.

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