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Sustained release of the model proteins from the biodegradable matrices was observed.
This study was undertaken in order to explore the thermodynamic relationships between geochemical variables and protein composition for model proteins from a number of organisms adapted to different environments.
The degradation mechanism can also be employed for GSH-triggered release of model proteins from PEG-only hydrogels, providing an opportunity for targeted protein delivery over time scales unique from those of disulfide- or hydrolytic-mediated mechanisms.
Moreover, alginate coating onto the surface of chitosan microparticles could modulate the release behavior of BSA from alginate coated chitosan microparticles and could effectively protect model protein (BSA) from degradation in acidic medium in vitro for at least 2 h.
Moreover, alginate coating onto surface of chitosan microparticles could modulate the release behavior of BSA from alginate coated chitosan microparticles and could effectively protect model protein (BSA) from degradation against acidic medium (pH2) in vitro at least for 2 hours.
The release of the model protein BSA from these new systems was studied.
Model protein, lipase from Candida rugosa, was entrapped within hydrogels upon mild conditions that provided its protection from harmful environmental influences.
Model protein, lipase from Candida rugosa (CRL), was entrapped within hydrogels upon mild conditions that provide its protection from harmful environmental influences.
However, it remains to be seen if this method can be extended from model proteins to complex protein samples from diverse biological sources, where protease inhibitors can be present.
The release profiles of a model protein drug (BSA) from test hydrogels were studied under simulated gastric and intestinal media.
After evaluating morphology of the resulting CAPP system, in vitro release of small molecule drugs and a model protein was studied from both single and multilayered devices.
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