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GSM TIP also shows only the positive disturbances, but the IRI model predicts only the negative disturbances.
In fact, Wyss says that if software was properly accounted for in the GDP, his model predicts only "minor dips" for the economy during the first couple of quarters of the year 2000.
In the ARF model, oscillations are still produced but interestingly, the deterministic version of the ATM model predicts only one peak followed by fairly constant levels of total p53 and Mdm2 but at a level higher than the initial values.
Note that beyond 0.5M the predicted curve and some data points overshoot the value of one because 0.5M was used as a reference to calculate the depleted RRP fraction at the other concentrations, assuming complete depletion at 0.5M, whereas the model predicts only 94% depletion at this point.
As a matter of fact, the TCMC model predicts seven orders of magnitude decrease in the integrated response, when the input EGF concentration decreases from 10-2 ng/mL to 10-3 ng/mL, whereas, the published model predicts only four orders of magnitude decrease.
However, a purely thermal model predicts only a diffuse velocity transition that is inconsistent with the sharp transitions shown in this study and in many others (e.g. Rychert et al., 2007; Eaton et al., 2009; Fischer et al., 2010; Miller and Eaton, 2010; Levander and Miller, 2012).
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By contrast, the food effect estimated by simulating the plasma profiles with the PBPK model predicted only a slight delay in the peak plasma level (∼1 h), and modest increases in the Cmax and AUC of ∼1.9-fold and 1.3-fold in the fed state, respectively.
The model predicted only an effect on ERK1/2 for the H. pylori stimulus, but not for HGF treatment.
The model predicted only 49% of the breast cancers that actually occurred in the screened group of 1,900 women.
Contrary to our expectation the model predicted only a slight increase in relative risk with increasing duration of passive exposure.
It should be noted that the pseudo R for the model was only.025, indicating that, despite having four statistically significant predictor variables included, the overall model predicted only a very small portion of the variance in the outcome variable.
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Justyna Jupowicz-Kozak
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