If a column has no *'s, than the respective model population included at least one model each of the 33 observed shape classes.
The model population is truncated at 101 years of age.
During a 14-year run-in phase, the model population was vaccinated with TIV at current age-specific uptake rates.
Since the metaphysiological approach provides a unified framework for modeling population interactions at all trophic levels [21], [22], it is not surprising that it extends easily and natural to a Q-Q framework, though inertia associated with the purely abundance approaches is not that easily overcome (cf. [105]).
This result is noteworthy for two reasons: the highest activity groups comprised only 13.3% and 2.8% of the male and female model populations; and PrEP was introduced at endemic equilibrium when these high activity groups become saturated and play a lesser role in the spread of HIV-1 compared to earlier stage epidemics [52].
These methods assume no underlying evolutionary model but have been shown to be good at modeling population structure.
However, evaluations of the cost-effectiveness of celecoxib have produced conflicting results owing mainly to differences in model structures, populations at risk, probabilities, cost-effectiveness indicators, and relative drug prices across countries.
For example, while Sub-Saharan African populations generally tend to have a genome-wide excess of rare variants which probably reflects a history of recent growth, the frequency spectrum at NAT2 shows a marked excess of intermediate frequency variants (positive Tajima's D), which departed significantly from a neutral model of a population at equilibrium followed by rapid exponential growth.
Assuming a simple model of a population at constant size, mutational equilibrium, and neutrality, these different estimates are expected to be the same or to agree, given the associated variance (see Materials and Methods).
But even if our model were to overestimate the population-at-risk somewhat, important theoretical, practical and ethical issues need to be addressed.
