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In an attempt to increase model performance, these models have been combined in ensembles (ensemble modeling), thus constituting the first PCM study where ensemble PCM modeling is applied.
While these were not used in comparing model performance, these sequence differences resulted in 35 locations with a basic amino acid that had a different probability of prediction of cleavage between the published and predicted sequences.
In contrast to the average unbiased model performance, these performances are biased because they are tested on the entire dataset from which the WAVE score was derived (that is trained and validated).
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Sylvester et al. [ 33] performed bootstrap resampling of all the IPD available and then examined model performance in these samples, leading to a bias-corrected C-statistic.
Moreover, due to the lack of sufficient observational data in the tropics and over large portions of the southern hemisphere, at present we cannot access observed TOE and model performance in these regions.
Additionally, the application of radar precipitation data for improvement of the model performance at these scales via more accurate areal averaged rainfall intensities was tested.
Unless this domain is sufficiently explored with validation experiments, satisfactory model performance at these discrete, tested settings would be insufficient to ensure satisfactory model performance throughout the entire operational domain.
Additional details regarding model performance by these categories can be found in the Supporting Information.
Model performance for these ENMs under the various climate change scenarios was evaluated using AUC values (Additional file 2).
VPC plots stratified for relevant covariates (such as age or weight groups), doses, or routes of administration are commonly constructed to demonstrate model performance in these subsets.
Five hundred random samples of the cohort were used to define the 95% centiles for model performance parameters; these intervals did not alter when fewer samples were assessed, and so analysis was not performed beyond 500 samples.
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