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The number of model parameters remains similar to the case of conventional HMM/GMM.
Despite exceptionally rich data on the NF- κB dynamics, a large fraction of model parameters remains non-identifiable.
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The only free model parameter remains the choice of γ, the ratio of wave height to water depth at initial breaking, and a well-established standard parameter is used for all model runs.
One of the model parameters, however, remains more uncertain than the rest.
The model parameter α remains constant with increasing gas pressure, which verifies the previous assumption that the electron temperature is inversely proportional to gas pressure.
Even for a given model, estimating its input parameters remains a challenge, especially for complex material systems.
The optimal mathematical model needed to derive these parameters remains controversial, and different methods are available.
However, the manner of finding the optimal increment or decrement in the value of channel access parameters remains the main limitation of this AC model.
Despite the above choice of the parameters is very specific, our extensive simulations show that scenario we proposed remains unchanged for sufficiently broad class of the model parameters.
Despite the close agreement regarding variability among these analyses, significant uncertainty remains regarding the appropriate central tendency estimates (e.g., means, medians) for the model parameters and, consequently, for the output of the model.
The estimation of demographic parameters remains difficult because of the difficulties of verifying the hypothesis of the models used, of estimating accurate initial parameters (e.g., absolute date of domestication) and sometimes because of low sample sizes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com