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The model parameters (organ blood flow, volume, etc).
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A limitation of the model-based transformation of data on internal dose (U-Cd concentrations) to external dose levels (intake via diet and smoking) is that the model parameters (body weight, organ weight, and average consumption of different foods) are based on characteristics of an average consumer, and thus does not account for at-risk subpopulations such as females and smokers.
By contrast, model parameters for the two end-organ configurations in the third computational experiment were set as β = 5.658 × 10−8 mA, α = 2.545 × 10−14 mA/Pa, and λ = 5.882 × 10−11 mA∙ms/Pa, which represent the averages of all previous configuration parameters.
This needs to be supplemented by optimisation of models and model parameters to translate absorbed doses into equivalent, organ, biologically effective doses or any other indirect dose entities.
Parameterising cardiac cell models in a whole-organ context is important for multi-scale modelling and ultimately for clinical use of the models, and requires the ability to control and foresee the whole-organ consequences of variations in cell-level model parameters.
Table 2 Model parameters.
Estimation of model parameters.
Tune the model parameters.
Model parameters were estimated by RAxML.
The reversal potentials are free model parameters.
Model parameters are described in Table 1.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com