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Specifically, the time evolution of circular variance was used to estimate the model parameters (Figure 2).

was largely insensitive to model parameters (Supplementary Figure 4) or the time postinfection when the assessment of synergy is made (Supplementary Figure 7).

One-way sensitivity-analyses were performed on all key model parameters, and Figure 2 shows the variables found to have the most effect on the base-case ICER.

A number of taxa stand out as outliers either in the model's poor performance at predicting their predators or prey (figures 2 and 3) or in their best-fit model parameter values (figures 4 and 5).

Figure 3 illustrates how the best policy relates to individual model parameters, and Appendix figures 7, 8 show the distributions of individual parameters where treatment increases or decreases resistance.

The back-end was fixed as a two-state HMM with a 6-mixture GMM modelling each state and various combinations of descriptors (slope, initial and midpoint values) of the different source-filter model parameter contours (Figure 4) used as features and the UAR determined for each setup.

Table  4 presents the posterior estimates of the four model parameters (see also Figure 4).

The corresponding model parameters are shown in Figure  1B and Figure  1C displays the fitting process implemented.

Both of these states are referred to as antiphase in the extraction of parameters in Figure 5 and Figure 7. 10.7554/eLiFigure50.015 Figure 7. Model parameters.

The dynamics of S T of AP-1 for the most sensitive model parameters are presented in Figure 5A, while S T for all parameters are given in Additional file 1, Figure S3.

Plots of the pdf for some combinations of values of the model parameters are given in Figure 1.

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