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The sensitivity analysis of the model parameters confirmed that the initial dose and receptor concentrations were indeed the two parameters that had the largest influence on the variance in antigen concentrations within the cells and circulation at equilibrium.
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With regard to the engineering application, the successful identification of the true model by minimizing a multimodal misfit functional for wide feasible bounds of the model parameters confirms that waveform inversion by the improved global optimization method is promising for practical applications with real measurement data.
We then compared the theoretical posture calculated by the mathematical model described in the method section to identify the model parameters and confirm the validity of the proposed model.
The cost-effectiveness of rituximab induction and maintenance based on the 5-year follow-up results was robust to changes in the key model parameters and was confirmed with one-way sensitivity analysis, cost-effectiveness acceptability frontier (CEAF), and multinomial expected value of perfect information (mEVPI) methods.
We discuss the development of the concept of ART for the prevention of HIV transmission and the modeled impact that a test-and-treat strategy could have on the HIV epidemic, and consequently argue that a field trial should be carried out to confirm model parameters, highlight any practical problems, and test the model's predictions.
The comparison between computer simulations performed by determined model parameters with the experimental results confirm the correctness of this mathematical driver model and identified model parameters.
Cremezi confirmed that the model parameters are still quite sensitive, and interference generated by turbulence, may introduce significant differences with the experimental results.
The final model was evaluated using bootstrap analysis, confirming that the model parameters could be estimated with good precision (Table 2).
This also confirms the reasonable hydrological model parameters.
The analysis of variance (ANOVA) was employed to confirm the adequacy of the model parameters.
Log-likelihood profiling of all the model parameters and additional diagnostic plots (data not shown) all confirmed the acceptable performance of the final selected model.
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